The Human Subjects Office\IRB has issued a detailed explanation of regulatory changes affecting research occurring at the University of Iowa. As of 1/21/19, the Human Subjects Research (Common Rule) regulatory changes outlined under §45 CFR 46 have gone into effect for all new and pending research submitted to the University of Iowa IRB for review. A 2019 SOP and Investigator's Guide has been released to capture these changes. If you have any questions on how these changes affect your research, call (319) 335-6564 or email irb@uiowa.edu the Human Subjects Office.